The significance of reduced glutathione and glutathione S-transferase during chemoradiotherapy of locally advanced cervical cancer
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چکیده
منابع مشابه
Genetic Polymorphism of the Glutathione S-Transferase M1 and Development of Breast Cancer
Glutathione S-transferases (GSTs) are encoded by a superfamily of genes and play a role in the detoxification of potential carcinogens. The human GSTs are divided into four classes: alpha, mu, pi and theta. Previous studies indicated that the absence of the Glutathione S-Transferase M1 (GSTM1) protein correlated with an increased risk of developing some types of cancers. Association between spe...
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GSTM1 and GSTT1 gene polymorphisms have been studied in many populations to evaluate their association with prostate cancer risk with contrasting results. The current study was aimed to find out the association of GSTM1 and GSTT1 gene polymorphisms with prostate cancer in Pakistani men. This case control study included pathologically confirmed prostate cancer patients and age matched male contr...
متن کاملInvestigating the rate of glutathione S-transferase T1 and M1 genes deletion in patients with lung cancer
Introduction: Glutathione S-tarnsferases (GST) gene family is one of the enzymes which is responsible for detoxifying mutagens and Carcinogens chemicals. People with null genotype of GSTM1 and GSTT1 genes are at higher risk of developing cancer, especially those who are related to smoking. The goal of this study was investigating the rate of glutathione S-transferase T1 and M1 genes deletion an...
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Reduced glutathione (GSH) and Glutathione S-transferase (GST) play important roles in the detoxification of several xenobiotic compounds, including pesticides. This study was carried out to access the effect of the organophosphate pesticide, dichlorvos on the activities of GSH, GST as well as lipid peroxidation of egg laying hens. Seven weeks old pullets weighing between 400-600 g divided into ...
متن کاملRegulation of catalase: inhibition by peroxynitrite and reactivation by reduced glutathione and glutathione S-transferase.
The regulation of stable catalase from Aspergillus niger was investigated. The preincubation of catalase with peroxynitrite (PN) resulted in a significant decrease in the production of O2, while the subsequent incubation with reduced glutathione (GSH, 1mM) led to restoration of the enzymatic activity. Western blot analysis revealed not only the increased immunoreactivities of 3-nitrotyrosine an...
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ژورنال
عنوان ژورنال: Medicina
سال: 2014
ISSN: 1010-660X
DOI: 10.1016/j.medici.2014.09.005